Research
DTU is becoming a global center for de novo protein design, focusing on designs that translate into real-world function.
Our research links computational protein design with automated experimentation and rigorous functional validation to accelerate the creation of proteins with real-world impact across health, biotechnology, materials, and environmental applications.
Main Research Aims
- Build integrated design–test pipelines that connect AI models with automated laboratory workflows.
- Advance the design of binders, enzymes, and novel protein functions with direct relevance for industry, healthcare, and materials science.
- Translate cutting-edge protein design into deployable solutions through strong partnerships with academic, clinical, and industrial collaborators
A common platform for research and toolbox development
- Computational Protein Design: Generative and predictive models for creating and evaluating new protein structures, interfaces, and functions.
- Automated Design–Test Workflows: Expression, screening, and characterisation carried out through automated and semi-automated pipelines to enable rapid iteration.
- Functional Characterization: Biophysical, biochemical, and cellular assays to confirm binding, activity, stability, and other application-relevant properties.
- Emerging Computational Methods: Exploring quantum algorithms and other advanced techniques for improved sampling, modelling, and design.
Use Cases
Therapeutics and Molecular Targets
- De novo binders for clinically relevant GPCRs and cytokines in the context of migraine
- Precision binders to peptide–MHC complexes for immunotherapy
- Neutralising proteins for snakebite and other toxins
- Protein scaffolds designed for intracellular delivery
Industrial and Bioengineering Applications
- Enzymes for bioindustrial processing with improved activity, specificity, and robustness
- Enzymes tailored for food and fermentation processes
- Biocatalysts for low-energy, low-waste production pipelines
- Binding proteins for bioprocess monitoring, purification, and sensing
Environmental and Materials Applications
- Enzymes for polymer and textile upcycling
- Protein-based systems for material recovery and metal binding
- Biodegradable protein adhesives, coatings, and functional materials
- Proteins supporting soil resilience and sustainable agriculture
These examples represent only a fraction of the opportunities where innovative protein design can transform industries and contribute to a more sustainable, circular bioeconomy.